Nature Made® product formulas may change from time to time. Please consult the label on the product that you purchased for product composition information.

TripleFlex Triple Strength with Vitamin D3

Nature Made TripleFlex® Triple Strength* provides key nutrients needed for daily joint support and muscle health support.

  • Supports joint comfort, mobility and flexibility
  • Provides Chondroitin, Glucosamine, MSM and Vitamin D3
60 / 120
2 Daily

Product Details

Nature Made TripleFlex® Triple Strength* with Vitamin D3 (2000 IU) has been formulated with TripleFlex’s key nutrients plus vitamin D3 to help support joint health and healthy bones.

  • Glucosamine (1500 mg): Helps support joint comfort, mobility and flexibility
  • Chondroitin (800 mg): Helps joint move smoothly by helping to support joint lubrication
  • MSM (750 mg): A source of dietary sulfur that is used by the body for building collagen, connective tissue and joint cartilage
  • Vitamin D3 (2000 IU): helps support healthy bones and muscles

Nature Made TripleFlex with Vitamin D3 caplet is guaranteed to meet our high quality standards – it is made from carefully selected ingredients under strict manufacturing processes.

  • No Artificial Flavors
  • No Preservatives
  • No Yeast
  • Gluten Free

2 caplet per day formula

Dosage and Interactions

When to Take:

Suggested Use: Take two caplets daily, with food. Caplets can be taken together or at different times during the day. For easier swallowing, take with water before and during ingestion.


Triple Flex Triple Strength* with Vitamin D3 should be used with caution when combined with:

  • Blood thinning medication (e.g. Warfarin and Coumadin)
  • Anti-diabetic drugs
  • Anti-neoplastic drugs
  • Nonsteroidal anti-inflammatory drugs (e.g. ibuprofen and aspirin)

Caution: If you are pregnant or nursing, or allergic to shellfish, consult your health care professional before taking this product.

Given that no two people are alike, if you are taking any medications you should be aware that potential drug-nutrient interactions may occur and are encouraged to consult a health care professional before using this product.  Combining certain prescription drugs and dietary supplements can lead to undesirable effects such as:

  • Diminished drug effectiveness
  • Reduced supplement effectiveness
  • Impaired drug and/or supplement absorption


Can I take all the caplets at one time?

The caplets can be taken at one time or at different times of the day.

Can this product be taken with other supplements?

Triple Flex® Triple Strength* with Vitamin D3 can be taken in combination with other Vitamin and Mineral supplements. There is no interaction.

Can this product be taken with other Triple Flex® formulations?

Research has shown 1500 mg of Glucosamine a day to be beneficial for supporting joint health. It is not necessary to combine more than one of the Triple Flex® formulations.

How much Vitamin D3 does this product provide?

Two caplets provide 750 IU of Vitamin D3.

Is this product recommended to be used only by those over the age of 50?

This product is suggested for those over the age of 50 years old as mature adults may need higher amounts of Calcium and Vitamin D for bone health. We do not recommend this product to be used by those under the age of 18 years old.

What benefit does Calcium and Vitamin D provide in this product?

Calcium and Vitamin D are both beneficial for bone health.

What is the suggested dosage for this product?

The suggested dosage is two caplets daily. The capsules can be taken either before or with a meal.


For 40 years, we have been obsessed with quality at Nature Made®. From ingredient sourcing, to industry-leading manufacturing practices, to our third-party verification approach, we believe it is our responsibility to lead in delivering quality products and a quality consumer experience. For more information, click here.